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Grafting data - Rshiny server for NBIS

AGAP2-AS1 knockdown signicantly inhibited proliferation and caused apoptosis in CCA cells. In addition, we demonstrated that AGAP2-AS1 promotes the proliferation of CCA. Conclusions: We conclude that the long non-coding RNA AGAP2-AS1 plays a role in promoting the proliferation of The lncRNA AGAP2-AS1 is located on a cytogenetic band in chromosome 12q14.1, which contains 1567 nucleotides (12q14.1 is the gene symbol of AGAP2-AS1 in HUGO Gene Nomenclature Committee 48633, entrez gene: 100130776, Ensemble: ENSG00000255737). 16 AGAP2-AS1 Silencer Select Pre-designed, Validated, and Custom siRNA in Standard, HPLC, and In-vivo Ready Purities. AGAP2-AS1 (≥ 0.6553; n = 56) and those with a low relative expression of AGAP2 AS1 (< 0.6553; n = 54).

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18 Feb 2021 However, the role and mechanism of AGAP2-AS1 in papillary thyroid carcinoma ( PTC) remain unclear. Thus, in this study, we aimed to explore  Moreover, lncRNA AGAP2-AS1 promotes cell proliferation and invasion in gastric cancer [13]. How- ever, the expression and its function roles of lncRNA. AGAP2-  25 Sep 2020 The current study aimed to elucidate the role of lncRNA AGAP2-AS1/miR-195-5p/ PDZ and LIM domain 5 (PDLIM5) in prostate cancer  5 Mar 2021 AGAP2-AS1 (AGAP2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AGAP2-AS1 include  18 Sep 2020 The lncRNA AGAP2 antisense RNA 1 (AGAP2-AS1) is Keywords: LncRNA, AGAP2-AS1, papillary thyroid cancer, miR-424-5p, MMP2. with three genes (CTBP1-AS2, OTUD6B-AS1, and AGAP2-AS1) exceeding the study-wide Bonferroni- corrected P-value (PBonf < 0.0023, Pcombined ¼ 1.1   OTUD6B-AS1 and AGAP2-AS1) exceeding the study-wide Bonferroni-corrected ρ-value.

High AGAP2-AS1 expression may predict a poor prognosis in GBM patients. The expression of AGAP2-AS1 and miR-16-5p in HCC specimens and cell lines were detected by real-time PCR. The correlation among AGAP2-AS1 and miR-16-5p were disclosed by a dual-luciferase reporter assay, RIP assay and biotin pull-down assay. AGAP2-AS1 is located on chromosome 12q14.1 and consists of 1567 nucleotides.

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If available, associations are ranked by standardized value The lncRNA AGAP2-AS1 is located on a cytogenetic band in chromosome 12q14.1, which contains 1567 nucleotides (12q14.1 is the gene symbol of AGAP2-AS1 in HUGO Gene Nomenclature Committee 48633, entrez gene: 100130776, Ensemble: ENSG00000255737). Long non-coding RNA (lncRNA) AGAP2-AS1 acts as an oncogene in several types of cancers. However, the role and mechanism of AGAP2-AS1 in papillary thyroid carcinoma (PTC) remain unclear. Thus, in this study, we aimed to explore the role of AGAP2-AS1 in PTC. Our results showed that AGAP2-AS1 was significantly upregulated in PTC tissues.

Gene ID Unique ID sequence Human GeCKOv2 B number

Please select a position: Gencode Genes AGAP2-AS1 (ENST00000542466.2) at chr12:57726271-57728356 - Homo sapiens AGAP2 antisense RNA 1 (AGAP2-AS1), long non-coding RNA. 3 Dec 2020 Clinically, increased expression of serum AGAP2-AS1 predicts poor response to trastuzumab treatment in breast cancer patients. In conclusion,  2 Mar 2021 LncRNA AGAP2-AS1 Promotes Cancer Cell Proliferation, Migration and Invasion in Colon Cancer by Forming a Negative Feedback Loop with  2 Mar 2021 LncRNA AGAP2-AS1 Promotes Cancer Cell Proliferation, Migration and Invasion in Colon Cancer by Forming a Negative Feedback Loop with  HGNC data for AGAP2-AS1.

RT-qPCR was performed to detect the differential expression of AGAP2-AS1 in tumor tissues and adjacent normal tissues. To test the interaction between AGAP2-AS1 and LINC-PINT in colon cancer, overexpression vector or inhibitor of AGAP2-AS1 and LINC-PINT were transfected into RKO and HCT 116 cells. CCK-8 assay was used to detect cell proliferation. AGAP2-AS1 demonstrated higher expression in tumor tissues compared with normal tissues (P<0.001; Fig. 1A). Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test. Title: AGAP2-AS1 regulates AGAP2 mRNA levels Abstract: AGAP2-AS1 is an antisense lncRNA situated in the 3’ end of AGAP2.
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As shown in Figure 3A, AGAP2-AS1 was localized mainly in the cytoplasm in TPC1 and K1 cells. To investigate whether AGAP2-AS1 may SP1 induced AGAP2-AS1 plays an important role in tumorigenesis. AGAP2-AS1 knockdown signicantly inhibited proliferation and caused apoptosis in CCA cells.

AGAP2-AS1 is upregulated in lung cancer and can interact with EZH2 and LSD1 to suppress the expression of LATS2 and KLF2, thereby promoting tumor growth. 11 In gastric cancer, SP1 activates AGAP2-AS1 to increase cancer cell migration and proliferation.
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Top Ten Agap2 - 100dichterinnen

Overexpression of AGAP2-AS1 promoted cell growth, suppressed apoptosis, and caused trastuzumab resistance, whereas knockdown of AGAP2-AS1 showed an opposite effect. AGAP2-AS1 mRNA expression and prognosis in pan-cancer analyses. Recognized as novel biomarkers in clinical settings, lncRNAs have an important impact on the development of solid tumors [31,32]. AGAP2-AS1 was downregulated in EOC tissues. (A) Differentially expressed lncRNAs between ovarian cancer (OC) tissues (n=267) and ovarian borderline tumors (n=18). (B) AGAP2-AS1 decreased in OC tissues compared to ovarian borderline tumors (P < 0.05, Student's t-test).

Top Ten Agap2 - 100dichterinnen

2018 ). AGAP2-AS1 promoted cell growth, suppressed apoptosis, and caused trastuzumab resistance, whereas knockdown of AGAP2-AS1 showed an opposite effect.

In addition, we demonstrated that AGAP2-AS1 promotes the proliferation of CCA. Conclusions: We conclude that the long non-coding RNA AGAP2-AS1 plays a role in promoting the proliferation of AGAP2-AS1 levels and clinicopathological features. Additionally, we investigated the functional impact of AGAP2-AS1 on tumor migration, invasion and proliferation during EOC progression through a series of in vitro and in vivo assays. Moreover, we also explored the molecular events that occurred AGAP2-AS1 was up-regulated and associated with poor prognosis in GBM. Knockdown of AGAP2 -AS1 suppressed proliferation and invasion, and facilitated apoptosis in GBM cells . To explore the functional relevance of AGAP2AS1 in - GBM cells, we interfered endogenous AGAP2-AS1 expression in U87/MG and U251/MG cells by AGAP2-AS1 was demonstrated as an oncogene in several cancers, including glioblastoma (GBM).